TGCT, also known as pigmented villonodular synovitis (PVNS)1, is a rare, non-malignant but locally aggressive tumor that can affect small and large joints.2 It is predominantly non–life-threatening but can have a significant impact on patients’ quality of life.1,3
5 and 45
Per Million
Patient-Years
Patient-Years
Incidence of TGCT diffuse-type (D-TGCT) and nodular-type (N-TGCT), respectively, in a European study4
35–50
Years
Typical age at diagnosis of TGCT1,2
PVNS/GCTTS
TGCT has previously been referred to as pigmented villonodular synovitis (PVNS) or giant cell tumor of tendon sheath (GCTTS)1
The symptoms of TGCT are generally nonspecific.2,5 Commonly reported symptoms include:
Pain5 
Swelling5 
Limited Rangeof Motion5
Stiffness5 TGCT tumor subtypes
TGCT comprises two clinically distinct subgroups, diffuse-type (D-TGCT) and nodular-type* (N-TGCT).1
TGCT affects the synovium, which lines joints, bursae and tendon sheaths. Tumors in both types of TGCT can be intra-articular or extra-articular; the most common tumor location for both subtypes is the knee.2,4,6
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- Most common subtype – accounts for ≈90% of cases7
- Impacts smaller joints, like fingers or wrists6
- Tumors are typically a single, well-defined mass6
- Often does not cause pain or joint dysfunction6
- Less common – accounts for ≈10% of cases7
- Impacts larger joints, like the hips or ankles6
- Tumors are more aggressive and destructive; they can extend beyond the joint and damage surrounding bone6
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