Tenosynovial giant cell tumor (TGCT, also known as pigmented villonodular synovitis [PVNS]), is a rare tumor, which can cause pain, disability and reduced work productivity, with substantial economic impact (e.g., sick leave, medical costs) and detrimental effects on QoL.1–3
Patients face a challenging journey, with delayed diagnosis and limited treatment options, often leaving them stuck in a surgery loop.1,3,4
The International Clinical Consensus suggests that TGCT treatment should be managed within expert centers or reference networks by a dedicated, experienced sarcoma multidisciplinary treatment team.2
View the International Clinical Consensus here
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Click here to find outPVNS, pigmented villonodular synovitis; QoL, quality of life; TGCT, tenosynovial giant cell tumor.
References:
- Berthnal NM, et al. Orphanet J Rare Dis. 2021;16(1):191.
- Stacchiotti S, et al. Cancer Treat Rev. 2023;112:102491.
- Lopez-Bastida J, et al. Orphanet J Rare Dis. 2021;16(1):294.
- Ansel S, et al. J Med Case Rep. 2023;17(1):419.
DCPH-P02491 | August 2025